NORTH NODE INSTITUTE OF NEUROSCIENCE & EPIGENETICS
Advancing non-invasive neuroscience for measurable human optimization.
Our Mission
To establish a new medical framework grounded in neuroplasticity, epigenetic modulation, and the brain's ability to regulate biological function through measurable cognitive and physiological mechanisms.
About Us
The North Node Institute of Neuroscience and Epigenetics (NNINE) is a private, accreditation-eligible research institute dedicated to advancing non-invasive, brain-centered approaches to healing and human optimization.
Our work focuses on the investigation of chronic and treatment-resistant conditions, neurophysiological dysregulation, and long-term functional outcomes using evidence-based, neuroscience-driven methodologies.NNINE integrates advanced neuroimaging, gene expression analysis, and structured neurocognitive training protocols to examine how targeted cognitive and physiological regulation influences neural adaptation and biological markers over time.Operating at the intersection of translational neuroscience and clinical research, the Institute is committed to rigorous experimental design, ethical governance, participant safety, and regulatory compliance.
Our Approach
Neuroplasticity-Based Healing
Leveraging the brain's natural ability to reorganize and form new neural connections for therapeutic outcomes.
Epigenetic Modulation
Using targeted interventions to influence gene expression and cellular function without altering DNA structure.
Measurable Outcomes
Employing advanced neuroimaging and biomarker analysis to track and validate therapeutic progress.
Evidence-Based Protocols
Developing rigorously tested, replicable interventions grounded in scientific methodology.
Non-Invasive Treatment
Focusing on non-invasive interventions that do not rely on pharmacological or surgical procedures.
Personalized Medicine
Tailoring interventions based on individual neurobiological profiles and genetic markers.
Principal Investigator
Shifa Maryyam
Distinction-Honored Neuroscientist, KCL
Founder & Principal Investigator
Shifa Maryyam is a distinction-honored neuroscientist trained at King’s College London and the Founder and Principal Investigator of the North Node Institute of Neuroscience and Epigenetics (NNINE). Her work focuses on advancing non-invasive, neuroscience-driven research frameworks that examine how cognitive and physiological regulation influence long-term biological outcomes.Her academic background spans neuroplasticity, epigenetic modulation, and brain–body regulatory mechanisms, with a particular emphasis on how stress-related neural states correlate with dysregulated biological function. This work has informed the development of NNINE’s proprietary Repatterning Technique (NRT™)—a structured, neuroscience-based research methodology integrating advanced neuroimaging, cognitive retraining paradigms, and gene expression analysis.Maryyam’s published research investigates the relationship between subconscious emotional processing, stress physiology, and chronic disease markers, proposing that targeted modulation of brain states may produce measurable, repeatable biological changes. The NRT™ framework is currently being evaluated through structured human-subject research initiatives conducted under scientific oversight and advisory guidance.NNINE operates at the intersection of translational neuroscience and clinical research, with ongoing collaboration and advisory input from senior researchers affiliated with institutions including Columbia University, Harvard University, and the University of Oxford.