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North Node Institute of Neuroscience and Epigenetics
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An Interdisciplinary Research Institute Shaping Next-Generation Medicine

Developing Non-Invasive Approaches to Disease Reversal

Investigating Brain Reprogramming and Gene Expression Regulation

NNINE is a private, accreditation-eligible research institute dedicated to advancing rigorous, measurable research in neuroscience and epigenetics. Our mission is to develop and evaluate non-invasive neurocognitive approaches that investigate the relationship between brain plasticity, stress regulation, and targeted gene expression, contributing to the development of next-generation models of medicine.

⚠️ IMPORTANT REGULATORY DISCLOSURE

The Northnode Institute of Neuroscience & Epigenetics (NNINE) is currently in the pre-clinical phase of its research operations and is not presently conducting formal clinical trials. NNINE is actively securing all required regulatory credentials, including Institutional Review Board (IRB) approval and establishment of a HIPAA-compliant framework. Until such formal designations are finalized, all participant interactions, evaluations, and data collection are conducted exclusively as part of an ongoing pre-study pilot research project.

Participation is strictly voluntary and contingent upon:

Execution of a comprehensive Informed Consent agreement
Adherence to mutual confidentiality and non-disclosure provisions
Formal acknowledgment that current activities do not constitute a clinical trial or medical treatment

A Joint Research Venture

Honorary board members from

Columbia University

Harvard University

Oxford University

Honorary Board of Advisory

The Advisory Board includes distinguished professors and academic leaders from top universities and institutions.

Prof. Jane Doe

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. John Smith

Prof. John Smith

Professor of Economics, ABC University

Prof. Alice Brown

Prof. Alice Brown

Chair of Political Science, LMN University

Prof. Jane Doe

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. Jane Doe

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. Jane Doe

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

CORE AREAS OF RESEARCH

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1. Non-Invasive Disease Reversal through Neuroplasticity and Epigenetics

Developing non-invasive research protocols that examine how behavioral, cognitive, and emotional modulation may influence neuroplasticity, epigenetic regulation, and chronic disease processes without pharmacological or surgical intervention.

Mind-Body-World Interaction
2. Mind–Matter Interaction and Consciousness–Reality Coupling

Investigating bidirectional interactions between consciousness and physical matter, including whether cognitive states and intention may exert measurable influence on material systems beyond the biological body, and how physical structures and environmental constraints reciprocally shape conscious experience.

Free Will and Subconscious
3. Neurobiology of Free Will, Subconscious Conditioning, and Artificial Consciousness

Exploring the neurobiological foundations of free will and subconscious conditioning, alongside experimental research into the emergence, induction, and modeling of consciousness within artificial intelligence systems, including the conditions under which conscious-like states may arise.

Additional Areas of Exploration

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Consciousness and Selfhood
4. Neuroscience of Consciousness and Selfhood

Investigating the neural basis of consciousness and selfhood, including whether conscious experience emerges solely from brain activity or may involve non-local, quantum, or extended mechanisms.

Sleep and Neural Recovery
5. Sleep, Brain Recovery, and Neural Regeneration

Examining how sleep and restorative neural states support brain recovery, functional reorganization, and regenerative processes associated with cognitive performance and neurological health.

Consciousness After Death
6. Consciousness at the Threshold of Death

Exploring conscious awareness during states of clinical death and extreme physiological stress, and investigating whether aspects of consciousness may persist beyond conventional biological function.

Brain-to-Brain Interface
7. Neural Communication and Inter-Brain Signaling

Researching the externalization, transmission, and interpretation of neural signals associated with thought and cognition through neuroimaging, computational modeling, and machine learning–based technologies.

Cross-Cutting Methodology Across All Areas

All NNINE research employs non-invasive, neuroscience-based methodologies with quantifiable markers, including neuroimaging, electrophysiology, biological data, and behavioral metrics. Research involving human participants is conducted under ethical standards aligned with IRB principles, with an emphasis on rigor, reproducibility, and public-good outcomes.

THE NNINE METHOD

Scientific Foundation & Active Research Outcomes

The NNINE Method is a multimodel research framework designed to examine how directed neuroplastic recalibration, emotional–physiological regulation, and cognitive state training interact to influence biological function and human performance. The protocol integrates measurable neural, biological, and behavioral markers within an active, ongoing pre-study research setting.To date, participant-reported outcomes include spontaneous remission of long-standing physical discomfort, restoration of functional mobility, marked improvements in mood regulation, cognitive clarity, and a return to baseline physiological stability in individuals with prolonged functional impairment.These early signals continue to guide refinement of the NNINE Method as structured data collection and formal evaluation progress. While research is ongoing, current findings suggest that targeted, non-invasive modulation of brain–body systems may play a significant role in restoring functional coherence across both mental and physical domains.

NNINE RESEARCH PROTOCOL STRUCTURE

Active Pilot Framework for Neuroplastic and Epigenetic Recalibration

Phase 1: Medical & Biological Profiling Animation

PHASE 1: Medical & Biological Profiling

  • Participant submits:
    • Full medical history
    • Bloodwork and hormone/genetic panels (required)
  • Case is reviewed by NNINE’s clinical research team to determine eligibility, safety parameters, and protocol suitability.
Phase 2: Initial Evaluation Animation

PHASE 2: Initial Evaluation by Principal Investigator

  • Participant books and pays for an evaluation.
  • PI conducts:
    • Emotional, behavioral, and neurocognitive profiling
    • Assessment of stress response, trauma history, and cognitive flexibility
    • Clinical notes prepared for board presentation.
    • Identification of dominant neurocognitive and autonomic dysregulation patterns
Phase 3: Scientific Advisory Board Review Animation

PHASE 3: Scientific Advisory Board Review

  • PI presents anonymized case data to NNINE’s Scientific Advisory Board.
  • Multidisciplinary review assesses biological plausibility, risk profile, and protocol alignment.
  • Approved cases proceed to individualized protocol calibration.
  • Participant pays remaining program fee
  • Anonymized use of clinical data for research
Phase 4: Baseline Neuroimaging Animation

PHASE 4: Baseline Neuroimaging (fMRI #1)

  • Participant books three fMRI sessions at their local neuroimaging center.
  • First fMRI: Resting-state scan (pre-intervention) to map default neural activity.
  • A neural-biological baseline is constructed by the NNINE research team.
  • This baseline is used to track functional coherence, network regulation, and adaptive change across the program.
Phase 5: Targeted Neural Reprogramming Animation

LEVEL 1: Regulation & Neural Stabilization

  • Daily structured protocol focused on nervous system stabilization and signal regulation.

  • Training emphasizes autonomic downregulation, interoceptive awareness, and baseline coherence.
  • Physiological state tracking and protocol responsiveness monitoring are initiated.
  • Regular check-ins ensure safety, compliance, and early adaptive shifts.
  • Emotional reconditioning tasks
  • Phase 6: Midpoint Neuroimaging Animation

    LEVEL 2: Focused Cognitive Training & Midpoint Evaluation

    • Participant undergoes targeted attention and executive-control training.
    • Second neuroimaging session may be conducted during active protocol engagement.
    • Neural activity is compared against baseline, and protocol parameters are refined to optimize signal efficiency, cognitive control, and autonomic balance.
    Phase 7: Consolidation Phase Animation

    LEVEL 3: Functional Consolidation & Adaptive Integration

    • Participant applies stabilized attention and regulatory capacity toward targeted functional objectives identified earlier in the program.
    • Training emphasizes intentional modulation of cognitive–emotional states under controlled conditions.
    • Protocols are designed to disrupt entrenched maladaptive patterns and reinforce adaptive neural responses.
    • Ongoing monitoring ensures changes are integrated without destabilization and remain within safe adaptive ranges.
    Phase 8: Neural Identity Coding Animation

    LEVEL 4: Neural Identity Coding & Stabilization

    • Participant engages in advanced identity-level integration protocols.
    • This procedure activates the mirror neuron system, insular cortex, and frontoparietal integration networks to re-pattern the brain's internal representation of self.
    • Neural systems involved in embodiment, intention, and self-referential processing are engaged to support durable functional reorganization.
    Phase 9: Final fMRI & Program Discharge Animation

    LEVEL 5: Final Neuroimaging & Program Discharge

    • Final neuroimaging session assesses durability of neural reorganization and system-level coherence.
    • Follow-up blood test or gene panel to assess physiological shifts
    • Principal Investigator conducts comprehensive final evaluation.
    • Participant receives individualized long-term neural maintenance guidance and relapse-prevention strategies.
    • Custom long-term neural maintenance tools

    Novelty & Intellectual Property Notice

    The NNINE Research Protocol is a novel, neuroscience-driven framework currently being evaluated within an active pilot program. While grounded in established scientific principles, the protocol’s structure and applied methodologies are internally developed and unique to NNINE. Specific operational details are intentionally not disclosed, as core components are protected as proprietary research architecture and trade secrets under NNINE ownership.

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    PATIENT TESTIMONIALS

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    Candidate 102.

    Candidate 107.