North Node Institute of Neuroscience and Epigenetics

Welcome to the new era of medical science

Reversing disease without drugs or surgery

Rewire the brain. Regulate gene expression. Control your biology.

NNINE is a private, accreditation-eligible research institute dedicated to unlocking the full potential of the human brain through rigorous, measurable research in neuroscience and epigenetics. Our mission is to develop and validate non-invasive methods to reverse chronic disease and eliminate physical, mental, and emotional suffering - establishing a new model of medicine grounded in brain plasticity and targeted gene expression.

⚠️ Legal Disclaimer

NNINE (Northnode Institute of Neuroscience & Epigenetics) is currently not conducting a formal clinical trial.
We are in the process of securing IRB approval, HIPAA compliance, and other regulatory clearances.
Until these approvals are finalized, all services, evaluations, and participant interactions are part of a pre-study project operated under North Node.

A Joint Research Venture

Honorary board members from

Columbia University

Harvard University

Oxford University

Honorary Board of Advisory

The Advisory Board includes distinguished professors and academic leaders from top universities and institutions.

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. John Smith

Professor of Economics, ABC University

Prof. Alice Brown

Chair of Political Science, LMN University

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

Prof. Jane Doe

Dean, Faculty of Social Sciences, XYZ University

CORE AREAS OF RESEARCH

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1. Non-Invasive Disease Reversal through Neuroplasticity and Epigenetics

Developing protocols to reverse chronic illness via behavior and emotional modulation without drugs or surgery.

2. Mind-Body-World Interaction and Extended Cognition

Studying how mind, body, and environment interact in cognition and awareness, including intuitive and field-based phenomena.

3. Neurobiology of Free Will and Subconscious Programming

Exploring how free will is shaped by genes, subconscious conditioning, and whether autonomy can be enhanced or influenced externally.

Additional Areas of Exploration

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4. Neuroscience of Consciousness and Selfhood

Investigating whether consciousness emerges from the brain or exists beyond the body, and how it interfaces with reality via neural or quantum mechanisms.

5. Sleep, Brain Recovery, and Neural Regeneration

Understanding how sleep restores neural functions and unlocks healing and cognitive enhancement potentials.

6. Consciousness at the Threshold of Death

Exploring awareness during clinical death and whether consciousness persists beyond physical life.

7. Neural Communication, Thought Decoding, and Brain-to-Brain Interface

Researching the externalization and transmission of thoughts through neuroimaging and machine learning technologies.

Cross-Cutting Methodology Across All Areas

All NNINE research uses non-invasive, neuroscience-based techniques with measurable markers (e.g., fMRI, EEG, blood data, behavior metrics). Ethical and IRB-compliant practices with human subjects ensure reproducibility and public-good outcomes.

NNINE METHOD

Scientific Basis of the NNINE Healing Protocol

The NNINE Healing Protocol is a multimodal clinical intervention designed to investigate the reversal of chronic or terminal illness through neuroplastic recalibration, gene expression shifts, and systemic emotional-physiological realignment. The protocol is grounded in measurable neuroscience and evidence-based behavioral medicine, structured for formal research under IRB and HIPAA compliance.

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Neuroplasticity

Utilizes Hebbian learning and long-term potentiation to rewire dysfunctional brain circuits.
Target: limbic-prefrontal dysregulation, often observed in chronic stress conditions.
Cited: Doidge (2015), Lutz et al. (2004)

Epigenetic Modulation

Behavioral and emotional state interventions modulate expression of genes involved in inflammation, repair, and stress response.
Cited: Szyf (2007), Lipton (2005)

Cognitive-Physiological Feedback

Internal psychological states affect immune, endocrine, and autonomic systems via top-down signaling.
Cited: Kirsch (1999), Dispenza (2020)

Neurocognitive Regulation Training animation

Neurocognitive Regulation Training (NRT)

Structured mental training: interoceptive focus, attentional control, affective recalibration.
Engages ACC, PFC, insula to reduce DMN overactivity and enhance executive function.
Includes respiratory entrainment, internal state awareness, and cognitive redirection.

Visual-Neural Encoding

Simulation of a "healed identity" activates mirror neuron systems aiding integrative recovery.
Cited: Ramachandran (2005)

NNINE CLINICAL PROTOCOL

Multiphase Healing Intervention Structure

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PHASE 1: Medical & Biological Profiling

Participant submits:

Full medical history
Bloodwork and hormone/genetic panels (required)

Case is reviewed by NNINE's clinical research team and stored for pre-approval.

PHASE 2: Initial Evaluation by Principal Investigator

Participant books and pays for an evaluation.
PI conducts:

Emotional, behavioral, and neurocognitive profiling
Assessment of stress response, trauma history, and cognitive flexibility
Clinical notes prepared for board presentation.

PHASE 3: Scientific Advisory Board Review

PI presents the anonymized case to NNINE's Advisory Board.
If case is approved:

Participant pays remaining program fee or
Applies for waiver by consenting to:
Anonymized use of clinical data for research
Optional testimonial and video documentation

Phase 4: Baseline Neuroimaging Animation

PHASE 4: Baseline Neuroimaging (fMRI #1)

Participant books three fMRI sessions at their local neuroimaging center.
First fMRI: Resting-state scan (pre-intervention) to map default neural activity.
A neural-biological baseline is constructed by the NNINE research team.

Phase 5: Targeted Neural Reprogramming Animation

PHASE 5: Targeted Neural Reprogramming (Weeks 1–3)

Daily 3-hour protocol, includes:

Neurocognitive Regulation Training (NRT):

Guided respiratory interoceptive training
Top-down attention control exercises
Emotional reconditioning tasks

Frequency-based auditory neurostimulation
Anti-inflammatory nutrition protocol
Behavioral reflection tasks
Sleep phase recalibration tools

PHASE 6: Midpoint Neuroimaging + Evaluation (fMRI #2)

Participant undergoes second fMRI during active simulation or NRT task.
PI compares brain activity with baseline and adjusts protocol as needed.
Interim behavioral and emotional assessment conducted.

PHASE 7: Consolidation Phase (Week 4-5)

Participant continues daily NRT and nutrition protocol.
Optional:

Weekly virtual check-ins or regulation coaching
Emotional setpoint recalibration through embedded affirmations

Goal: stabilize gains and enhance trait-level emotional flexibility.

Phase 8: Neural Identity Coding Animation

PHASE 8: Neural Identity Coding (Optional)

The participant engages in a mirror-based or 3D holographic simulation designed to project a coherent, healthy bodily identity.
This procedure activates the mirror neuron system, insular cortex, and frontoparietal integration networks to re-pattern the brain's internal representation of self.
Inspired by the clinical methods developed by Dr. V.S. Ramachandran, this phase aims to reinforce neural coherence between intention, embodiment, and physiological recovery.

PHASE 9: Final fMRI & Program Discharge

Final fMRI (#3): Conducted during end-of-program identity rehearsal
Optional:

Follow-up blood test or gene panel to assess physiological shifts

PI conducts final evaluation and issues:

Progress documentation
Custom long-term neural maintenance tools
Follow-up guidance on relapse prevention

Summary

The NNINE Healing Protocol is a highly structured, IRB-compliant neurobehavioral intervention that combines imaging, psychological regulation, molecular biology, and multisensory identity reprogramming to explore disease reversal. It targets both state-level and trait-level transformation through neurocognitive, affective, and genetic pathways.

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September 8, 2025

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